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Article

Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.

European journal of pharmacology - 15 Jan 2020

Zhang Yuqing, Anoopkumar-Dukie Shailendra, Arora Devinder, Davey Andrew K

Abstract excerpt

Neurodegenerative disease refers to a range of chronic and progressive disorders that are characterized by dysfunction and loss of neurons. Neurodegeneration involves protein misfolding, oxidative injury, impaired mitochondrial function, neurotrophin deficiency and may also involve neuroinflammation. The sirtuin family of proteins plays a key role in this process suggesting that modulation of sirtuin can modify...

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Identifiers

PMID: 31812544
DOI: 10.1016/j.ejphar.2019.172847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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