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Sirtuins: double players in Huntington's disease

10 Jul 2015

Abstract excerpt

Sirtuins are a conserved family of NAD(+)-dependent class III lysine deacetylases, known to regulate longevity. In mammals, the sirtuin family has seven members (SIRT1-7), which vary in enzymatic activity, subcellular distribution and targets. Pharmacological and genetic modulation of SIRTs has been widely spread as a promising approach to slow aging and neurodegenerative processes. Huntington's disease (HD) is a...

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PMID: 26163995
DOI: 10.1016/j.bbadis.2015.07.003

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