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Article

SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice.

PloS one - 1 Jan 2016

Tulino Raffaella, Benjamin Agnesska C, Jolinon Nelly, Smith Donna L, Chini Eduardo N, Carnemolla Alisia, Bates Gillian P

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder for which there are no disease-modifying treatments. SIRT1 is a NAD+-dependent protein deacetylase that is implicated in maintaining neuronal health during development, differentiation and ageing. Previous studies suggested that the modulation of SIRT1 activity is neuroprotective in HD mouse models, however, the mechanisms controlling SIRT1 activity are...

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Identifiers

PMID: 26815359
DOI: 10.1371/journal.pone.0145425
PMCID: PMC4731418

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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