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Article

Sirtuins as Modifiers of Huntington's Disease (HD) Pathology.

Progress in molecular biology and translational science - 1 Jan 2018

Neo Sin Hui, Tang Bor Luen

Abstract excerpt

Sirtuins and their pharmacological activators/inhibitors have been associated with a range of neuroprotective effects or disease modifying influences in neurological disorders. Huntington's disease (HD) is an autosomal-dominant, progressive neurodegenerative disease characterized by movement disorder, psychiatric symptoms and cognitive decline. The monogenic mutation in HD encodes a variant of the protein...

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PMID: 29413175
DOI: 10.1016/bs.pmbts.2017.11.013

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HTT

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