Article
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
The EMBO journal - 11 Jul 2007
Kim Dohoon, Nguyen Minh Dang, Dobbin Matthew M, Fischer Andre, Sananbenesi Farahnaz, Rodgers Joseph T, Delalle Ivana, Baur Joseph A, Sui Guangchao, Armour Sean M, Puigserver Pere, Sinclair David A, Tsai Li-Huei
Abstract excerpt
A progressive loss of neurons with age underlies a variety of debilitating neurological disorders, including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS), yet few effective treatments are currently available. The SIR2 gene promotes longevity in a variety of organisms and may underlie the health benefits of caloric restriction, a diet that delays aging and neurodegeneration in mammals. Here, we...
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