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Neuronal protection by sirtuins in Alzheimer's disease

7 Oct 2005

Abstract excerpt

Silent information regulator 2, a member of NAD+-dependent histone deacetylase in yeast, and its homologs in mice and humans, participate in numerous important cell functions, including cell protection and cell cycle regulation. The sirtuin family members are highly conserved evolutionarily, and are predicted to have a role in cell survival. The science of sirtuins is an emerging field and is expected to...

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PMID: 16219030
DOI: 10.1111/j.1471-4159.2005.03492.x

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