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SIRT1 in the brain—connections with aging-associated disorders and lifespan

1 Jan 2015

Abstract excerpt

The silent mating type information regulation 2 proteins (sirtuins) 1 of class III histone deacetylases (HDACs) have been associated with health span and longevity. SIRT1, the best studied member of the mammalian sirtuins, has a myriad of roles in multiple tissues and organs. However, a significant part of SIRT1's role that impinges on aging and lifespan may lie in its activities in the central nervous system...

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PMID: 25805970
DOI: 10.3389/fncel.2015.00064

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