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Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective

5 Dec 2020

Abstract excerpt

Sirtuins are class III histone deacetylase (HDAC) enzymes that target both histone and non-histone substrates. They are linked to different brain functions and the regulation of different isoforms of these enzymes is touted to be an emerging therapy for the treatment of neurodegenerative diseases (NDs), including Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). The...

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PMID: 33280374
DOI: 10.1021/acschemneuro.0c00696

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