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Article

SIRT1 as a therapeutic target for Alzheimer’s disease

6 Aug 2016

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent cause of dementia in the aging population worldwide. SIRT1 deacetylation of histones and transcription factors impinge on multiple neuronal and non-neuronal targets, and modulates stress response, energy metabolism and cellular senescence/death pathways. Collectively, SIRT1 activity could potentially affect multiple aspects of hippocampal and cortical neuron function...

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PMID: 27497424
DOI: 10.1515/revneuro-2016-0023

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