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The Role of Sirtuin 1 (SIRT1) in Neurodegeneration

15 Jun 2023

Abstract excerpt

Sirtuins (SIRT) are a class of histone deacetylases that regulate important metabolic pathways and play a role in several disease processes. Of the seven mammalian homologs currently identified, sirtuin 1 (SIRT1) is the best understood and most studied. It has been associated with several neurodegenerative diseases and cancers. As such, it has been further investigated as a therapeutic target in the treatment of...

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PMID: 37456463
DOI: 10.7759/cureus.40463

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