Article

Precision-cut liver slices as a model for evaluating therapeutic agents against hepatitis B and delta viruses

2025-12-06

Abstract excerpt

<h4>Background: </h4> Developing new therapeutic strategies against hepatitis B virus (HBV) and hepatitis delta virus (HDV) is essential to cure these infections. Yet evaluation of host-targeting agents (HTAs) with in vitro/in vivo models remains challenging. Therefore, we assessed precision-cut liver slices (PCLS) as an HBV/HDV co-infection model to study virus-host interactions and HTAs. <h4>Methods:</h4> We gen...

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Literature Corpus work: 73dca88c-b562-5439-a19a-bb25742ffef5
DOI: 10.64898/2025.12.06.692712

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