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Article

Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis

16 Jun 2022

Abstract excerpt

Drugs are often withdrawn from the market due to the manifestation of drug-induced liver injury (DILI) in patients. Drug-induced cholestasis (DIC), defined as obstruction of hepatic bile flow due to medication, is one form of DILI. Because DILI is idiosyncratic, and the resulting cholestasis complex, there is no suitable in vitro model for early DIC detection during drug development. Our goal was to develop a...

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PMID: 35708773
DOI: 10.1007/s00204-022-03321-2

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