Article

APOBEC Mutagenesis is Concordant Between Tumor and Viral Genomes in HPV Positive Head and Neck Squamous Cell Carcinoma

2021-02-27

Abstract excerpt

APOBEC (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like) is a major mutagenic source in human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC). Why APOBEC mutations predominate in HPV+OPSCC remains an area of active investigation. Prevailing theories focus on APOBECs role as a viral restriction agent. APOBEC-induced mutations have been identified in both human cancers and...

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Literature Corpus work: 223f9e1e-f685-55f8-9dc4-f8e1c11ea2b1
DOI: 10.1101/2021.02.27.433168

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