Article

Human and viral whole genome sequencing identify HPV and APOBEC as oncogenic drivers in sinonasal squamous cell carcinoma

2026-02-09

Abstract excerpt

Sinonasal squamous cell carcinoma (SNSCC) is an aggressive head and neck cancer of the sinonasal cavity which has not benefitted from therapeutic advances over decades 1 . Though historically attributed to inhaled carcinogens such as hardwood dust and tobacco smoking 2 , SNSCC is incidentally associated with human papillomavirus (HPV) 3,4 . Importantly, HPV is the primary oncogenic driver of >80% of anatomicall...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2b5b46c7-78b5-5e3f-9a82-74999fd20f18
DOI: 10.64898/2026.02.04.26345593

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human and viral whole genome sequencing identify HPV and APOBEC as oncogenic drivers in sinonasal squamous cell carcinomaDOI 10.64898/2026.02.04.26345593Read

APOBEC Mutagenesis Is Concordant between Tumor and Viral Genomes in HPV-Positive Head and Neck Squamous Cell Carcinoma.Semantic proximity Read

Molecular patterns and mechanisms of tumorigenesis in HPV-associated and HPV-independent sinonasal squamous cell carcinomaSemantic proximity Read

APOBEC Mutagenesis is Concordant Between Tumor and Viral Genomes in HPV Positive Head and Neck Squamous Cell CarcinomaSemantic proximity Read

Human papillomavirus genomics: Understanding carcinogenicitySemantic proximity Read

Oncogenic Human Papillomaviruses Drive One-Third of Sinonasal Squamous Cell Carcinoma and Are Not Mutually Exclusive for Gene Mutations.Semantic proximity Read

Molecular Insights into HPV-Driven Head and Neck Cancers: From Viral Oncoproteins to Precision TherapeuticsSemantic proximity Read

Molecular mechanisms and diagnostic innovations in HPV-associated head and neck squamous cell carcinomas: Insights into integration, epigenetic modifications, and biomarker applicationsSemantic proximity Read

Super-pangenome analysis of 3562 human and animal papillomavirus isolates illuminates their genome and pathogenicity evolutionSemantic proximity Read

Virology and molecular pathogenesis of HPV (human papillomavirus)associated oropharyngeal squamous cell carcinomaSemantic proximity Read

The landscape of viral associations in human cancers.Semantic proximity Read

Differences in the viral genome between HPV-positive cervical and oropharyngeal cancerSemantic proximity Read

Oncogenic viruses rewire the epigenome in human cancerSemantic proximity Read