Article

Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC

2019-03-25

Abstract excerpt

Immune checkpoint inhibition leads to response in some patients with head and neck squamous cell carcinoma (HNSCC). Robust biomarkers are lacking to date. We analyzed viral status, gene expression signatures, mutational load and mutational signatures in whole exome and RNA-sequencing data of the HNSCC TCGA dataset (N = 496) and a validation set (DKTK MASTER cohort, N = 10). Public single-cell gene expression data...

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Literature Corpus work: ccbcc1aa-38f0-5e83-bfa3-5e35c43e8107
DOI: 10.1101/586396

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