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APOBEC Mutagenesis Is Concordant between Tumor and Viral Genomes in HPV-Positive Head and Neck Squamous Cell Carcinoma.

Viruses - 23 Aug 2021

Faden Daniel L, Kuhs Krystle A Lang, Lin Maoxuan, Langenbucher Adam, Pinheiro Maisa, Yeager Meredith, Cullen Michael, Boland Joseph F, Steinberg Mia, Bass Sara, Lewis James S, Lawrence Michael S, Ferris Robert L, Mirabello Lisa

Abstract excerpt

APOBEC is a mutagenic source in human papillomavirus (HPV)-mediated malignancies, including HPV+ oropharyngeal squamous cell carcinoma (HPV + OPSCC), and in HPV genomes. It is unknown why APOBEC mutations predominate in HPV + OPSCC, or if the APOBEC-induced mutations observed in both human cancers and HPV genomes are directly linked. We performed sequencing of host somatic exomes, transcriptomes, and HPV16...

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Identifiers

PMID: 34452530
DOI: 10.3390/v13081666
PMCID: PMC8402723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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