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Article

HPV+ oropharyngeal squamous cell carcinomas from patients with two tumors display synchrony of viral genomes yet discordant mutational profiles and signatures.

Carcinogenesis - 11 Feb 2021

Faden Daniel L, Langenbucher Adam, Kuhs Krystle, Lewis James S, Mirabello Lisa, Yeager Meredith, Boland Joseph F, Bass Sara, Steinberg Mia, Cullen Michael, Lawrence Michael S, Ferris Robert L

Abstract excerpt

Human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (HPV + OPSCC) is increasing in prevalence in the USA, as are cases of patients with multiple HPV + OPSCCs (mHPV + OPSCC). mHPV + OPSCCs present a unique opportunity to examine HPV + OPSCC mutation acquisition and evolution. We performed sequencing of the viral genome, somatic exome and somatic transcriptome from 8 patients each with 2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33075810
DOI: 10.1093/carcin/bgaa111
PMCID: PMC8014522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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