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Article

HPV Meets APOBEC: New Players in Head and Neck Cancer.

International journal of molecular sciences - 30 Jan 2021

Riva Giuseppe, Albano Camilla, Gugliesi Francesca, Pasquero Selina, Pacheco Sergio Fernando Castillo, Pecorari Giancarlo, Landolfo Santo, Biolatti Matteo, Dell'Oste Valentina

Abstract excerpt

Besides smoking and alcohol, human papillomavirus (HPV) is a factor promoting head and neck squamous cell carcinoma (HNSCC). In some human tumors, including HNSCC, a number of mutations are caused by aberrantly activated DNA-modifying enzymes, such as the apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) family of cytidine deaminases. As the enzymatic activity of APOBEC proteins contributes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33573337
DOI: 10.3390/ijms22031402
PMCID: PMC7866819

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