Article

Protein interaction network analysis of mTOR signaling reveals modular organization

2023-08-04

Abstract excerpt

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that acts as a central mediator of translation, and plays important roles in cell growth, synaptic plasticity, cancer, and a wide range of developmental disorders. The signaling cascade linking lipid kinases (PI3Ks), protein kinases (AKT) and translation initiation complexes (EIFs) to mTOR has been extensively modeled, but does not fully describ...

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Literature Corpus work: 2232a716-4ba4-5d76-9515-5fa3c092887f
DOI: 10.1101/2023.08.04.552011

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