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Evolution of growth factor signaling to the TSC complex to regulate mTORC1

8 Jul 2025

Abstract excerpt

The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates signals from factors that both stimulate (exogenous growth factors) and are essential for (intracellular nutrients and energy) cellular growth. Activation of the protein kinase mTOR within mTORC1 results in the phosphorylation of downstream substrates that collectively stimulate biomass accumulation to drive cell growth. Many upstream...

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PMID: 40627686
DOI: 10.1126/scisignal.adw4165

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