Article

Dissociation of the mTOR protein interaction network following neuronal activation is altered by Shank3 mutation

2025-05-23

Abstract excerpt

The mechanistic target of Rapamycin (mTOR) kinase pathway plays critical roles in neuronal function and synaptic plasticity, and its dysfunction is implicated in numerous neurological and psychiatric disorders. Traditional linear models depict mTOR signaling as a sequential phosphorylation cascade, but accumulating evidence supports a model that includes signaling through dynamic protein-protein interaction networ...

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Literature Corpus work: 1f6b42fa-22c2-532d-9b46-e995be459ddb
DOI: 10.1101/2025.05.20.655155

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