Article

Mathematical modelling of brain mTOR activity identifies selective vulnerability of cell types and signalling pathways

2022-12-15

Abstract excerpt

The mTOR pathway is a global regulator of protein biosynthesis and cellular homeostasis. Understanding the differences in mTOR pathway activity between cell types is important for elucidating the role of mTOR in physiological and pathophysiological processes. The non-linear structure of the pathway, with multiple feedback loops and inputs complicates the interpretation of experimental data and requires mathematica...

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Literature Corpus work: 67de5dcd-3002-53bd-8df0-1261af3c608a
DOI: 10.1101/2022.12.15.505685

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