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Article

Dissociation of the mTOR Protein Interaction Network Following Neuronal Activation Is Altered by Shank3 Mutation.

Journal of neurochemistry - 1 Jan 2026

Wehle Devin T, Brown Emily A, Stamenkovic Vera, Kniffen Breann, Harsh Felicia M, Smith Stephen E P

Abstract excerpt

The mechanistic target of Rapamycin (mTOR) kinase pathway plays critical roles in neuronal function and synaptic plasticity, and its dysfunction is implicated in numerous neurological and psychiatric disorders. Traditional linear models depict mTOR signaling as a sequential phosphorylation cascade, but accumulating evidence supports a model that includes signaling through dynamic protein-protein interaction...

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Identifiers

PMID: 41532697
DOI: 10.1111/jnc.70353
PMCID: PMC12802388

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