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Article

Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.

Genes & development - 15 Dec 2016

Davoli Teresa, Mengwasser Kristen E, Duan Jingjing, Chen Ting, Christensen Camilla, Wooten Eric C, Anselmo Anthony N, Li Mamie Z, Wong Kwok-Kin, Kahle Kristopher T, Elledge Stephen J

Abstract excerpt

Activating mutations in the phosphoinositide 3-kinase (PI3K) signaling pathway are frequently identified in cancer. To identify pathways that support PI3K oncogenesis, we performed a genome-wide RNAi screen in isogenic cell lines harboring wild-type or mutant PIK3CA to search for PI3K synthetic-lethal (SL) genes. A combined analysis of these results with a meta-analysis of two other large-scale RNAi screening...

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Identifiers

PMID: 28087713
DOI: 10.1101/gad.290122.116
PMCID: PMC5238728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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