Article

MicroRNA-Mediated Rewiring of the PI3K–AKT–mTOR Axis Reveals Divergent Regulatory Networks and Metabolic Vulnerabilities in Endometriosis-Associated Ovarian Cancers (EAOCs)

2026-07-20

Abstract excerpt

<h4>Background: </h4> Endometriosis-associated ovarian cancers (EAOCs), including clear cell (OCCC) and endometrioid (EnOC) subtypes, frequently activate the PI3K/AKT/mTOR signaling axis. While genomic aberrations are well documented, the coordinated mi-croRNA (miRNA)-mediated networks governing post-transcriptional remodeling of this pathway across these subtypes remain poorly defined. <h4>Methods:</h4> We conduc...

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Literature Corpus work: 1914ad8b-95d3-585b-89a0-b21a92639172
DOI: 10.20944/preprints202607.1410.v1

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