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Article

Protein interaction network analysis of mTOR signaling reveals modular organization.

The Journal of biological chemistry - 1 Nov 2023

Wehle Devin T, Bass Carter S, Sulc Josef, Mirzaa Ghayda, Smith Stephen E P

Abstract excerpt

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that acts as a central mediator of translation and plays important roles in cell growth, synaptic plasticity, cancer, and a wide range of developmental disorders. The signaling cascade linking lipid kinases (phosphoinositide 3-kinases), protein kinases (AKT), and translation initiation complexes (EIFs) to mTOR has been extensively modeled, but...

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Identifiers

PMID: 37741456
DOI: 10.1016/j.jbc.2023.105271
PMCID: PMC10594569

Genes

MTOR
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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