Article

A theoretical and experimental framework enables low-coverage sequencing for accurate quantification of genome-wide cytosine modification levels

2025-01-12

Abstract excerpt

<h4>ABSTRACT</h4> 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) regulate gene expression and exhibit dynamic levels during development and disease. While high-depth, base-resolution studies offer the most detailed view of epigenetic landscapes, many open questions are answered by surveying changes in 5mC/5hmC levels across larger cohorts. Nonetheless, current global quantification methods, including m...

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Literature Corpus work: 2202fc48-bf45-55d1-9a63-bf9c3b7631f3
DOI: 10.1101/2025.01.08.631958

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