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Article

Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome.

Genome biology - 5 Jul 2016

Gravina Silvia, Dong Xiao, Yu Bo, Vijg Jan

Abstract excerpt

BACKGROUND: Transmission fidelity of CpG DNA methylation patterns is not foolproof, with error rates from less than 1 to well over 10 % per CpG site, dependent on preservation of the methylated or unmethylated state and the type of sequence. This suggests a fairly high chance of errors. However, the consequences of such errors in terms of cell-to-cell variation have never been demonstrated by experimentally...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27380908
DOI: 10.1186/s13059-016-1011-3
PMCID: PMC4934005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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