Article

Epigenetic control of Topoisomerase 1 activity presents a cancer vulnerability

2024-10-25

Abstract excerpt

DNA transactions introduce torsional constraints that pose an inherent risk to genome integrity. While topoisomerase 1 (TOP1) activity is essential for removing DNA supercoiling, aberrant stabilization of TOP1:DNA cleavage complexes (TOP1ccs) can result in cytotoxic DNA lesions. What protects genomic hot spots of topological stress from aberrant TOP1 activity remains unknown. Here, we identify chromatin context as...

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Literature Corpus work: 21dcebea-3019-5b01-9277-2679ab1dec12
DOI: 10.1101/2024.10.22.619113

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