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Article

Top1-PARP1 association and beyond: from DNA topology to break repair

1 Feb 2021

Abstract excerpt

Selective trapping of human topoisomerase 1 (Top1) on the DNA (Top1 cleavage complexes; Top1cc) by specific Top1-poisons triggers DNA breaks and cell death. Poly(ADP-ribose) polymerase 1 (PARP1) is an early nick sensor for trapped Top1cc. New mechanistic insights have been developed in recent years to rationalize the importance of PARP1 beyond the repair of Top1-induced DNA breaks. This review summarizes the...

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PMID: 33981998
DOI: 10.1093/narcan/zcab003

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