Article

A naïve piRNA Surveillance System That Broadly Monitors the Germline Transcriptome for Adaptive Genome Defense

2024-01-24

Abstract excerpt

PIWI-interacting RNAs (piRNAs) safeguard germline genomes from invasive genetic elements such as transposons. While long-term silencing relies on sequence-specific mechanisms such as ping-pong amplification and the incorporation of invader fragments into genomic piRNA clusters, how newly invading elements are initially recognized as “non-self” remains unresolved. Here, we show that low levels of sense-stranded piR...

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Literature Corpus work: 21da9713-cde0-548e-bbf2-520bb4512b09
DOI: 10.1101/2024.01.24.577019

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