Article

A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements

2026-02-09

Abstract excerpt

<h4>ABSTRACT</h4> How piRNA-mediated genome defense achieves specificity against transposons while sampling a complex transcriptome has remained unresolved. Here we show that piRNA biogenesis operates through pervasive, non-specific sampling of cytoplasmic RNAs, with specificity imposed by tissue-specific molecular modules that exploit intrinsic vulnerabilities of transposons. In Drosophila somatic cells, the spe...

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Literature Corpus work: db02bdb2-75bc-54ee-8311-a0a8feb61f6e
DOI: 10.64898/2026.02.07.704324

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