Article

CERTL reduces C16 ceramide, amyloid-β levels and inflammation in a model of Alzheimer's disease

2021-01-11

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Dysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer’s disease (AD). Ceramide transfer proteins (CERTs) are ceramide carriers which are crucial for ceramide and sphingomyelin balance in cells. Extracellular forms of CERTs co-localize with amyloid-β (Aβ) plaques in AD brains. To date, the significan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 21bea0cc-45d9-534d-8600-fa6e094335ce
DOI: 10.21203/rs.3.rs-42740/v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CERTL reduces C16 ceramide, amyloid-β levels and inflammation in a model of Alzheimer's diseaseDOI 10.21203/rs.3.rs-42740/v3Read

CERTL Reduces C16 Ceramide, Amyloid-β Levels and Inflammation in a Model of Alzheimer's DiseaseSemantic proximity Read

Gas6 Induces Inflammation And Reduces Plaque Burden But Worsens Behavior In The APP/PS1 Model of Alzheimer’s DiseaseSemantic proximity Read

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse.Semantic proximity Read

Maresin-like 1 Ameliorates Neuropathology of Alzheimer's Disease in Brains of a Transgenic Mouse ModelSemantic proximity Read

Alhydrogel TM , a widely used adjuvant, modulates multiple networks implicated in brain aging and has potential in the prevention of age-related cognitive declineSemantic proximity Read

Simple gangliosides co-localize with amyloid plaques and increase with age in a transgenic mouse model of Alzheimer’s diseaseSemantic proximity Read

Deletion of Specific Sphingolipids in Distinct Neurons Improves Spatial Memory in a Mouse Model of Alzheimer’s DiseaseSemantic proximity Read

GABAergic signaling abnormalities in a novel CLU mutation Alzheimer's disease mouse model.Semantic proximity Read

GM2 ganglioside accumulation causes neuroinflammation and behavioral alterations in a mouse model of early-onset Tay-Sachs disease.Semantic proximity Read

The 5XFAD Mouse Model of Alzheimer's Disease Exhibits an Age-Dependent Increase in Anti-Ceramide IgG and Exogenous Administration of Ceramide Further Increases Anti-Ceramide Titers and Amyloid Plaque Burden.Semantic proximity Read

Ganglioside enriched phospholipid vesicles induce cooperative Aβ oligomerization and membrane disruptionSemantic proximity Read

Enhancing Retromer Complex Stability Ameliorates Synaptic Dysfunction in a Mouse Model of Alzheimer’s DiseaseSemantic proximity Read