Article

Simple gangliosides co-localize with amyloid plaques and increase with age in a transgenic mouse model of Alzheimer’s disease

2024-10-07

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) is a progressive neurodegenerative disease accounting for two-thirds of all dementia cases, and age is the strongest risk factor. Beyond the amyloid hypothesis, lipid dysregulation is now recognized as a core component of AD pathology. Gangliosides are a class of membrane lipids of the glycosphingolipid family and are enriched in the central nervous system (CNS)...

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Literature Corpus work: d80ee851-a713-56d6-ba8e-754ae8146648
DOI: 10.21203/rs.3.rs-5182325/v1

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