Article

Tumor-derived colorectal cancer organoids induce a unique Treg cell population through direct modulation of CD4 <sup>+</sup> T cell differentiation

2024-07-22

Abstract excerpt

In colorectal cancer (CRC), increased numbers of tumor-infiltrating CD4 + regulatory T (Treg) cells correlate with tumor development and immunotherapy failure, leading to poor prognosis. However, the molecular and cellular mechanisms governing Treg recruitment, expansion, or differentiation remain unclear. Here, we developed an in vitro co-culture system to assess the capacity of CRC tumors to directly modulate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 21af7217-6a88-55bd-8a18-247d73f0df2a
DOI: 10.1101/2024.07.18.604049

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tumor-derived colorectal cancer organoids induce a unique Treg cell population through direct modulation of CD4 <sup>+</sup> T cell differentiationDOI 10.1101/2024.07.18.604049Read

Tumor-derived colorectal cancer organoids induce a unique Treg cell population by directing CD4+ T cell differentiationSemantic proximity Read

Site-dependent Treg cell transcriptional reprograming in a metastatic colorectal cancer model holds prognostic significanceSemantic proximity Read

Multi-omics analyses of single cell-derived colorectal cancer organoids reveal intratumor heterogeneity and immune response diversitySemantic proximity Read

Integrated Single‐Cell RNA ‐Seq Reveals Immunosuppressive Mechanisms of Treg Cell Differentiation and Tumor Microenvironment Interactions in Colorectal CancerSemantic proximity Read

Identification of an immune overdrive high-risk subpopulation with aberrant expression of FOXP3 and CTLA4 in colorectal cancer.Semantic proximity Read

FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity.Semantic proximity Read

Human intestinal organoids with an autologous tissue-resident immune compartmentSemantic proximity Read

GITR and TIGIT immunotherapy provokes divergent multi-cellular responses in the tumor microenvironment of gastrointestinal cancersSemantic proximity Read

Complex Role of Regulatory T Cells (Tregs) in the Tumor Microenvironment: Their Molecular Mechanisms and Bidirectional Effects on Cancer ProgressionSemantic proximity Read

Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistanceSemantic proximity Read

Tumors accumulate expanded GATA3-dependent tissue TregsSemantic proximity Read

TGF-β signaling redirects Sox11 gene regulatory activity to promote partial EMT and collective invasion of oncogenically transformed intestinal organoidsSemantic proximity Read