Article

Multi-omics analyses of single cell-derived colorectal cancer organoids reveal intratumor heterogeneity and immune response diversity

2022-11-25

Abstract excerpt

Colorectal cancer (CRC) organoids have similar genomic and functional characteristics to the original specimens. They have become a novel and promising tumor model. However, systematic research of heterogeneity and evolution based on tumor organoids and unbiased evaluation of CD4 + T cell-mediated tumor recognition is presently lacking. Here, we study the variability in genomic characterization and single-cell tr...

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Literature Corpus work: a0d7ecff-3342-56f1-af2a-da00ea1fda16
DOI: 10.1101/2022.11.25.517889

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