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Tumor-derived colorectal cancer organoids induce a unique Treg cell population by directing CD4+ T cell differentiation

18 Jan 2025

Abstract excerpt

In colorectal cancer (CRC), increased numbers of tumor-infiltrating CD4 + regulatory T (Treg) cells correlate with tumor development, immunotherapy failure, and poor prognosis. To assess how CRC tumors directly modulate Treg cell differentiation, we developed an in vitro co-culture system using CD4 + T cells from Foxp3eGFP mice and CRC tumor-derived organoids. Co-culture resulted in a significant increase in Treg...

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PMID: 39995881
DOI: 10.1016/j.isci.2025.111827

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