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Article

Identification of an immune overdrive high-risk subpopulation with aberrant expression of FOXP3 and CTLA4 in colorectal cancer.

Oncogene - 1 Mar 2021

Cui Kaisa, Yao Surui, Zhang Han, Zhou Mingyue, Liu Bingxin, Cao Yulin, Fei Bojian, Huang Shenglin, Huang Zhaohui

Abstract excerpt

Colorectal cancer (CRC) is characterized by a heterogeneous tumor microenvironment (TME) that regulates cancer progression and therapeutic response. Overexpression of FOXP3 and CTLA4 is associated with immunosuppressive TME and poor prognosis in many cancer types. However, opposite results were reported in CRC. Thus, we performed comprehensive analyses to evaluate the exact prognostic value of FOXP3 and CTLA4 in...

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PMID: 33627780
DOI: 10.1038/s41388-021-01677-w

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