Article
Templated Insertions Are Associated Specifically with BRCA2 Deficiency and Overall Survival in Advanced Ovarian Cancer.
Molecular cancer research : MCR - 6 Jul 2022
Moore Grace, Majumdar Rahul, Powell Simon N, Khan Atif J, Weinhold Nils, Yin Shen, Higginson Daniel S
Abstract excerpt
Cancer cells defective in homologous recombination (HR) are responsive to DNA-crosslinking chemotherapies, PARP inhibitors, and inhibitors of polymerase theta (Pol θ), a key mediator of the backup pathway alternative end-joining. Such cancers include those with pathogenic biallelic alterations in core HR genes and another cohort of cases that exhibit sensitivity to the same agents and harbor genomic hallmarks of...
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