Article

Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens

2024-03-14

Abstract excerpt

Substance use disorder is characterized by a maladaptive imbalance wherein drug seeking persists despite negative consequences or drug unavailability. This imbalance correlates with neurobiological alterations some of which are amplified during forced abstinence, thereby compromising the capacity of extinction-based approaches to prevent relapse. Cocaine use disorder (CUD) exemplifies this phenomenon in which neur...

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Literature Corpus work: d23b1c8d-8ed7-5bcd-b95a-75664df75e0f
DOI: 10.1101/2024.03.12.584637

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