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Article

Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIalpha in the nucleus accumbens is critical for motivation for drug reinforcement.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2010

Wang Lei, Lv Zhigang, Hu Zhaoyang, Sheng Jian, Hui Bin, Sun Jie, Ma Lan

Abstract excerpt

The regulation of gene expression in the brain reward regions is known to contribute to the pathogenesis and persistence of drug addiction. Increasing evidence suggests that the regulation of gene transcription is mediated by epigenetic mechanisms that alter the chromatin structure at specific ge...

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Source

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Identifiers

PMID: 20010550
DOI: 10.1038/npp.2009.193
PMCID: PMC3055366

Genes

HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20010550-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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