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Article

Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import.

Neuron - 12 Jan 2012

Taniguchi Makoto, Carreira Maria B, Smith Laura N, Zirlin Benjamin C, Neve Rachael L, Cowan Christopher W

Abstract excerpt

Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulated nuclear import of HDAC5 requires a signaling mechanism that involves transient, protein phosphatase 2A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22243750
DOI: 10.1016/j.neuron.2011.10.032
PMCID: PMC3259532

Genes

HDAC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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