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HepG2 cells with knockouts of <i>CYP51A1</i> , <i>DHCR24</i> or <i>SC5D</i> from cholesterol synthesis accumulate sterols influencing distinct regulatory pathways

2023-05-19

Abstract excerpt

<h4>ABSTRACT</h4> Sterol intermediates of cholesterol synthesis are largely dedicated to cholesterol. Here we assess how they influence downstream gene regulatory pathways by developing knockouts (KOs) for consecutive enzymes of cholesterol synthesis in human hepatoma HepG2 cells. The KO of CYP51 , DHCR24 , and SC5D led to the build-up of specific sterols. The shared differentially expressed genes accounted fo...

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Literature Corpus work
21483ca6-d7e8-529a-8699-ebd52f5fa9bd
DOI
10.1101/2023.05.19.538399
Open publication

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HepG2 cells with knockouts of <i>CYP51A1</i> , <i>DHCR24</i> or <i>SC5D</i> from cholesterol synthesis accumulate sterols influencing distinct regulatory pathwaysDOI 10.1101/2023.05.19.538399
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