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CYP51A1 in health and disease: from sterol metabolism to regulated cell death

14 Jul 2025

Abstract excerpt

How do cells precisely coordinate sterol metabolism with survival and death signals in diverse physiological and pathological contexts? This fundamental question has gained increasing attention as accumulating evidence reveals that enzymes traditionally associated with lipid biosynthesis may have unexpected regulatory functions beyond metabolism. Cytochrome P450 family 51 subfamily A member 1 (CYP51A1), a...

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PMID: 40659633
DOI: 10.1038/s41420-025-02621-7

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