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Article

Sex-dependent pathways in hepatocarcinogenesis triggered by deregulated cholesterol synthesis

2020-09-04

Abstract excerpt

<h4>ABSTRACT</h4> We uncover novel pathways of sex-dependent hepatocarcinogenesis due to chronic repression of cholesterol synthesis at the lanosterol 14α-demethylase (CYP51) step. The response to metabolic insult determined by global liver transcriptome, qPCR and sterol metabolite analysis, together with blood parameters, revealed molecular signatures that differ between females and males. The data deduced from...

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Literature Corpus work
6f94a3fd-d785-55f8-b459-9f400f0f7c8c
DOI
10.1101/2020.09.03.280974
Open publication

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Sex-dependent pathways in hepatocarcinogenesis triggered by deregulated cholesterol synthesisDOI 10.1101/2020.09.03.280974
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