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Article

Hidden disease susceptibility and sexual dimorphism in the heterozygous knockout of Cyp51 from cholesterol synthesis.

PloS one - 1 Jan 2014

Lewinska Monika, Juvan Peter, Perse Martina, Jeruc Jera, Kos Spela, Lorbek Gregor, Urlep Ziga, Keber Rok, Horvat Simon, Rozman Damjana

Abstract excerpt

We examined the genotype-phenotype interactions of Cyp51+/- mice carrying one functional allele of lanosterol 14α-demethylase from cholesterol biosynthesis. No distinct developmental or morphological abnormalities were observed by routine visual inspection of Cyp51+/- and Cyp51+/+ mice and fertility was similar. We further collected a large data-set from female and male Cyp51+/- mice and controls fed for 16 weeks...

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Identifiers

PMID: 25393872
DOI: 10.1371/journal.pone.0112787
PMCID: PMC4231084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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