Article

Limitations of lymphoblastoid cell lines for establishing genetic reference datasets in the immunoglobulin loci

2021-07-15

Abstract excerpt

Lymphoblastoid cell lines (LCLs) have been critical to establishing genetic resources for biomedical science. They have been used extensively to study human genetic diversity, genome function, and inform the development of tools and methodologies for augmenting disease genetics research. While the validity of variant callsets from LCLs has been demonstrated for most of the genome, previous work has shown that DNA...

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Literature Corpus work: 213c0ba8-2898-5762-9eae-cdaf3329a0ff
DOI: 10.1101/2021.07.15.452448

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