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Article

Limitations of lymphoblastoid cell lines for establishing genetic reference datasets in the immunoglobulin loci.

PloS one - 1 Jan 2021

Rodriguez Oscar L, Sharp Andrew J, Watson Corey T

Abstract excerpt

Lymphoblastoid cell lines (LCLs) have been critical to establishing genetic resources for biomedical science. They have been used extensively to study human genetic diversity, genome function, and inform the development of tools and methodologies for augmenting disease genetics research. While the validity of variant callsets from LCLs has been demonstrated for most of the genome, previous work has shown that DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34898642
DOI: 10.1371/journal.pone.0261374
PMCID: PMC8668129

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