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In depth comparison of an individual’s DNA and its lymphoblastoid cell line using whole genome sequencing

14 Sept 2012

Abstract excerpt

BACKGROUND: A detailed analysis of whole genomes can be now achieved with next generation sequencing. Epstein Barr Virus (EBV) transformation is a widely used strategy in clinical research to obtain an unlimited source of a subject's DNA. Although the mechanism of transformation and immortalization by EBV is relatively well known at the transcriptional and proteomic level, the genetic consequences of EBV...

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PMID: 22974163
DOI: 10.1186/1471-2164-13-477

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