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Article

Genetic and genomic stability across lymphoblastoid cell line expansions.

BMC research notes - 3 Aug 2018

Scheinfeldt Laura B, Hodges Kelly, Pevsner Jonathan, Berlin Dorit, Turan Nahid, Gerry Norman P

Abstract excerpt

OBJECTIVE: Lymphoblastoid cell lines are widely used in genetic and genomic studies. Previous work has characterized variant stability in transformed culture and across culture passages. Our objective was to extend this work to evaluate single nucleotide polymorphism and structural variation across cell line expansions, which are commonly used in biorepository distribution. Our study used DNA and cell lines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30075799
DOI: 10.1186/s13104-018-3664-3
PMCID: PMC6076395

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